[Purposes] To study the active power coordination control characteristics of a hydropower station under a multi-energy complementary operation mode. [Methods] The active power control model of a hydropower station under a multi-energy complementary regulation mode is constructed, and the response ability is evaluated by the power-grid assessment standard. The influence of different water heads and regulation parameters on the coordinated control characteristics of the hydropower station is analyzed, and the parameters are optimized by a genetic algorithm.[Findings] The regulation performance of the hydropower station is better under low water heads, and it is easy to produce output oscillation and poor regulation under high water heads. The larger the pulse period is, the easier the output oscillation occurs. The smaller the maximum pulse width, the better the regulation characteristics of the hydropower station. The minimum pulse width affects the adjustment accuracy; the smaller the pulse width calculation parameter and the governor integration time constant are, the faster the adjustment is, but it is easy to oscillate. The larger the parameter is, the more stable the adjustment is, but the tracking ability is poor. The optimal parameters obtained by the genetic algorithm have good real-time output tracking and meet the grid assessment. [Conclusions] Under high water heads, the coordinated control ability of regulating active power of the hydropower station is poor, and the regulation is easy to produce overshoot and oscillation. The adjustment parameters of the unit have a great influence on the coordinated control ability of the hydropower station. If the value is improper, it will lead to poor regulation performance. Using genetic algorithms to optimize the adjustment parameters can effectively improve the power regulation quality of multi-energy complementary system.