[Purposes] To provide the scientific basis of suitable control scheme for high fill engineering design， the sensitivity of different control factors for post-construction settlement of high fill foundation in loess gully region were studied by this paper. [Methods] The modified Cambridge model parameters of Quaternary Late Pleistocene (Q3) loess under different vertical loads, water content and compactness are studied by laboratory experiments. The sensitivity of the factors affecting the post-construction settlement of high fill foundation is compared and analyzed by the numerical software PLAXIS. [Findings] The modified compression index，modified rebound coefficient and modified creep index of the Quaternary Late Pleistocene (Q3) loess firstly increase and then decrease with the vertical load and water content，and linearly increase with the compaction degree. The water content，compaction degree and fill height of the filler have significant influence on the post-construction settlement of high-fill foundation， while the width of the bottom of the gully， slope， thickness of the original foundation， fill rate， pile length， pile spacing and pile diameter have little influence on it. [Conclusions] The design height of high fill projects in loess gully region should be reduced as far as possible， and the water content of fill should be controlled to make it close to the optimal water content. Furthermore，location of fill should be selected in the region with little loess thickness， gully slope greater than 75° and gully bottom width less than 100 m.