[Purposes] Explore the safety of autonomous vehicles.[Methods] Firstly, this paper analyzes the current situation of self-driving car safety research at home and abroad and summarizes it. Then, this paper summarizes the reasons why self-driving vehicles cannot avoid collision and analyze the complex environment inside and outside the car, and discusses the coping strategies of self-driving car collision safety problems. Finally, this paper makes an outlook on the improvement of self-driving car collision safety. [Findings] At present, there are still many immature aspects of intelligent technology, especially the safety aspects of self-driving cars still need more research and experiments, such as obstacle recognition, intelligent decision-making and the interior space and layout of self-driving cars. [Conclusions] The use of self-driving technology in cars makes drivers have a safer and more comfortable driving experience, researchers should focus on the "human-centered" point of view, pay attention to human needs, protect human safety, design and develop intelligent technologies around "human-centered".