[Purposes] This work aims to optimize the dosage of waste tire pyrolysis carbon black(TPCB) additive in asphalt mixture to improve the comprehensive performance. [Methods] First, the response surface method (RSM) based on the central composite design was used for experimental design, and relevant tests were carried out on the formed Marshall specimen. Then, the influence of preparation parameters was analyzed, and the response variables was predicted by mathematical modeling. [Findings] The results showed that adding TPCB significantly improved the high?temperature stability of the asphalt mixture, and 4.56% asphalt and 5.32‰ TPCB were the optimal dosages. The results predicted by the established model agreed with the experimental results. [Conclusions] Therefore, RSM could also be effectively applied in the field of asphalt mixture, and TPCB asphalt mixture additive had a broad application prospect.