Solution blowing is a new technology that uses high?speed air flow to stretch and refine polymer solution to form nanofibers, which has the characteristics of high preparation efficiency, simple equipment structure and high preparation safety, etc. In this review, based on the introduction of solution blow spinning technology, the preparation process of solution blowing nanofiber was described, and the main factors affecting its structure and morphology were analyzed. Moreover, the application of solution blow spinning nanofiber in life science fields was emphasized, including tissue engineering, wound dressing, drug release, and fruit and vegetable preservation materials, and the development trend of solution blowing technology was also prospected.