[Purposes] In order to meet the needs of high?precision mass manufacturing, the simulation and experiment of precision hot pressing for aspherical phosphate glass lenses are combined to explore the influence of hot pressing parameters on lens residual stress, molding quality and optical properties. [Methods] Firstly, based on the analysis of the characteristics of thermal viscoelasticity, structural relaxation and heat transfer, the values of glass thermodynamic parameters were obtained. Then, the influence of process parameters such as pressing temperature, load and annealing rate on lens residual stress and its distribution were analyzed by finite element analysis. Finally, the pressing experiments were carried out. The effects of above process parameters on pressing quality such as contour offset, shape accuracy FPV and surface roughness Ra, and optical properties such as refractive index, reflectivity, transmittance of lens central, were discussed. The optimized process parameters were also obtained. [Findings] Increasing pressing temperature, reducing load and annealing rate were all beneficial to reduce lens residual stress. The optimal pressing temperature was 560 ℃, the optimal load was 1.1 MPa, and the optimal annealing rate was 0.125 ℃/s. By using optimized parameters, the FPV, Ra and maximum contour offset of lens aspheric surfaces ASP1 and ASP2 are 406.3, 829.6 nm, 14.5, 15.4 nm, and 38.2, 75.2 nm, respectively.The transmittance was greater than 86% in the detection wavelength of 400~900 nm. [Conclusions] The method of combining the simulation analysis of residual stress with the experimental analysis of molding quality can effectively explore the influence of the corresponding process parameters on the molding law, which play a role in optimizing the processing conditions.The molded lens with optimized parameters can meet the requirements of lens precision and optical properties.