［Purposes］ The paper aims to improve the road performance of asphalt pavement and realize the recycling of domestic waste incineration bottom slag.［Methods］ The difference between municipal solid waste incineration （MSWI） bottom slag and limestone machine-made sand was evaluated through laboratory test, and the feasibility of replacing machine-made sand with MSWI bottom slag was analyzed; Through the mix proportion design, the mineral aggregate gradation and the optimum oil-stone ratio of AC-16C asphalt mixture were determined when the MSWI bottom slag contents were 0%, 10%, 20% and 30%, respectively; The road performance of AC-16C asphalt mixture with different MSWI bottom slag contents was studied, such as high-temperature rutting resistance, low-temperature cracking resistance and water damage resistance.［Findings］ When the content of MSWI bottom slag is 10%, the high-temperature rutting resistance of the mixture is the best; When the content of MSWI bottom slag is 20%, the low-temperature cracking resistance of the mixture is the best; When the content of MSWI bottom slag is 10%, the water stability of the mixture is the best.［Conclusions］ The initial construction cost of MSWI bottom slag asphalt pavement is lower.