For the pump-stopping water hammer of the pressure pipeline system of the pump station, the self-operated control valve can effectively weaken the pressure rise of the pipeline caused by the pump-stopping water hammer, but cannot eliminate the negative pressure in the pipeline. In order to make the negative pressure of the pipeline reach the standard, a real project was taken as an example to compare and analyze the water hammer protection schemes of self-operated control valve by using the numerical simulation method of HAMMER software. In the simulation, the self-operated control valve was the basis, and the air valve and the one-way surge tank were combined to protective the water hammer equipments, which made the positive pressure and negative pressure of the water hammer in the pipeline to reach the standard. The simulation results show that self-operated control valve plus air valve can replace the function of one-way surge tank in the pipeline system, the water hammer protection scheme can ensure the safety of the pipeline system, reduce the capital investment in the protection of pump-stopping water hammer.