In order to study the coupling influence of soluble salt in snow-melting agent and fog on the performance of asphalt pavement, three kinds of asphalt mixtures often used in engineering, namely common AC-13C, modified AC-13C and modified SMA-13, were selected to research. The salt pray test was used to analyze the change rules of the low-temperature cracking resistance ability, water damage resistance ability and durability of different types of asphalt mixtures in salt-fog environment. The research results show that modified asphalt mixtures behave better than common asphalt mixtures at the pavement performance mentioned above in salt-fog environment. The modified SMA-13 asphalt mixture has the best low-temperature cracking resistance ability and water damage resistance ability. When the number of freeze-thaw cycle is more than 15, the decrease magnitude of the freeze-thaw splitting strength and the freeze-thaw splitting residual strength ratio of the modified SMA-13 asphalt mixture is the smallest in the three asphalt mixtures, which indicates that its durability is the best in the later stage.