In order to study the mechanical characteristics of pile foundation under slope soil seismic shear deformation, an integrated numerical model of the slope-pile foundation system was established by combining the Pressure Dependent Multi Yield(PDMY) and the pile-soil dynamic spring model. By inputting the EI-centro seismic wave with an amplitude of 0,480 9 g and considering different slope angles and pile diameters, a nonlinear dynamic time history calculation was performed. The results show that under the action of seismic load, the shear deformation of the slope soil is various at different depths, and the force of slope pile group foundation is unbalanced. The slope angle controls the shear deformation development of the slope soil and the residual bending moment of the pile, while the pile diameter has a smaller effect on them. The research work may provide some reference for the aseismic design of slope pile foundation.