In order to analyze the mechanical fat igue damage characteristics of asphalt mix-tures affected by meso-structure， a two-dimensionnal numerical model was established usingfinite element software to analyze the mechanicaland fatigue damage characteristics ofas-p halt mixtures based on meso-scale and indoors plit ting testresults.The results show thatin the fatigue damage process of asphalt mixturethe stress concentration near the sharpcorner of coarse aggregate is obvious， and fatiguedamage often first occurs at the sharp cor-ner of coarse aggregate.AC-13C numerical modelabove 2.36mm， and illustrate the feasibility of 2.36mmas the demarcation line of AC-13Cshould fully consider the coarse aggregatecoarse aggregate on theme so-scale.