The risk regionalization of highway slope disasters was studied according to the situation of frequent geological disasters and the regional distribution characteristics of highway slope in Danba County. By analyzing the natural environment and highway geological hazard characteristics, the slope, rock and soil types, rainfall, river network density and vegetation coverage as the main factors were selected to build risk assessment index system. Based on the superposition method of the influencing factors, the mathematical model of the risk assessment index was established, and the weight of each evaluation index is calculated by using cloud model-analytic hierarchy process (CM-AHP method).Based on the software of ENVI5.2 and ArcGIS10.2, the hazard index map of "Danba county highway slope geological hazard" was plotted. In view of the hazard zoning index and the characteristics of highway engineering, the highway slope disasters in Danba county was divided into 4 grade 16 disaster areas, such as the low risk area, medium dangerous area, high dangerous area, extremely high danger area. According to the evaluation method of quantitative regionalization range and qualitative analysis, the geological disasters risk assessment of highway in Danba county was carried out. The evaluation results coincide with the actual situation of highway slope disaster, which can provide a new way for the prevention and treatment of Danba County Highway slope disaster in Sichuan province.