The asphalt content is up to 95% or more in Venezuela Rock Asphalt (VRA), which is a kind of hard natural asphalt with high in asphalt content, less in ash and impurities and easy to process. In order to analyze the applicability of VRA for being used to asphalt modifier, and through selecting the AC-13C type of asphalt mixture commonly used in the surface layer and five different mixing amounts of VRA mass ratio of VRA to its modified asphalt mixture from 0% to 1% in accordance with the 0.25% intervals, the mix design and pavement performance verification for VRA modified asphalt mixture are carried out. Firstly, based on the results of mix design of common asphalt mixture, and according to the principle that the pure asphalt and mineral in VRA replace the equivalent base asphalt and mineral powder in the common asphalt mixture respectively, the adjustment formulas of mix design are proposed for the VRA modified asphalt mixture. Meanwhile, through the comparisons of two mixing processes between dry method and wet method, the temperature ranges and dry process which are suitable for mixing VRA modified asphalt mixture are determined. Lastly, the pavement performances of modified asphalt mixture under different VRA mixing amounts are tested respectively. The results show that, along with the increase of VRA mixing amount, all the Marshall stability, dynamic stability, flexural tensile strength and stiffness modulus of VRA modified asphalt mixture have accelerative increasing changes, both the residual stability and freeze-thaw splitting tensile strength ratio increase first and then decrease, the flow value has decreasing change, the maximum flexural tensile strain has gently accelerate decreasing change, and both the surface water permeability coefficient and texture depth have little changes. Therefore, it shows that the mixing VRA can effectively enhance the whole bond behavior and deformation resistance for the VRA modified asphalt mixture, significantly increase the high temperature stability and fatigue resistance and effectively improve the water stability, but it has some adverse effects on the low temperature crack resistance and no obvious effects on the surface impermeability and skid resistance. The VRA is more suitable for the use of asphalt pavement in the southern areas. According to the test results, it is suggested that the suitable range of mixing amount of VRA is 0.25%~0.75% of the mass of its modified asphalt mixture.