Due to road intersections’ complex structure, road data are prone to problems and defects of inconsistencies. In order to solve the topological inconsistency problems of intersections in road network, the detailed investigation of the categories, description and expression of inconsistency of road intersections based on topological relation models are performed. The topological relations between vertices and segments’ buffers of road intersections are analyzed closely with respect to the structural characteristics of intersections of road network, then a method of detecting inconsistency for road intersections based on structural topological relations is proposed. The method is implemented with Visual Studio 2008 and ArcEngine components. The experimental results show that this method detects inconsistencies accurately and efficiently, including conflicting vertices adjacent to other close roads at intersections, overshoots or undershoots of intersections vertex, etc.