In order to research the rheological property of the bio-binder modified asphalt HMA, to further investigate the road performance of the compound modified asphalt HMA of high and low temperature, the basic performance of matrix asphalt and bio-binder is tested, and the optimum content of bio-binder in bio-binder modified asphalt is determinded; high and low temperature bending creep test of the compound modified asphalt and 70^# asphalt AC-13 HMA is carried out. High and low temperature performance of compound modified asphalt HMA by plastic deformation, S, m, m/Svalue and energy dissipation ratio and other parameters based on the Burgers model are evaluated. The results show that the bio-binder is more temperature sensitive than the matrix asphalt,the bio-binder’s optimum content in the compound modified asphalt is 10% of the matrix asphalt,the high temperature property of the compound modified asphalt HMA is worse than the matrix asphalt HMA, but fulfil the requirements of specification,its low temperature property and stress relaxation properties are also worse than the matrix asphalt HMA.